What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide whose non-standard amino-acid residues distinguish it from endogenous ghrelin. It acts in the growth-hormone secretagogue pathway associated with GHS-R1a, the ghrelin receptor. That target differs from the GHRH receptor, even though both pathways can converge on growth-hormone release from pituitary somatotrophs.
Early pharmacology compared ipamorelin with GHRP-2, GHRP-6 and GHRH. In the defined swine experiments, growth-hormone release occurred without the significant ACTH and cortisol increases seen with the older GHRPs. This explains the interest in relative selectivity, while avoiding a blanket claim that every hormonal response is absent in every setting. Other animal work examines pituitary adaptation, bone dimensions and gastrointestinal motility. Each endpoint adds a separate piece of physiology rather than confirming a universal profile for the compound.
Ipamorelin Research Areas
Ipamorelin stimulated growth-hormone release in rat pituitary cells and animal experiments. In swine comparisons, GHRP-2 and GHRP-6 raised ACTH and cortisol, while ipamorelin did not produce significant increases above the GHRH comparison. This is the basis for its relative selectivity under those conditions, rather than a guarantee of an identical hormonal profile in every model.
Raun et al. · Eur J Endocrinol · 1998PubMed
Prior ipamorelin exposure changed secretory-granule density and subsequent growth-hormone responses in pituitary cells from young female rats. The basal proportion of somatotrophs stayed similar across groups. This distinguishes adaptation in secretion and hormone content from a simple increase in the number of growth-hormone-producing cells.
Jiménez-Reina et al. · Histol Histopathol · 2002PubMed
Higher bone mineral content after ipamorelin in female rats reflected larger bones, not an increase in their intrinsic mineral density. Volumetric density and mineral concentration were unchanged after growth was accounted for. Distinguishing bone size from bone density is essential when interpreting these 12-week animal findings.
Svensson et al. · J Endocrinol · 2000PubMed
Molecular profile
- Compound
- Ipamorelin
- Amount
- 5 mg
- Sequence
- Aib-His-
D-2-Nal-D-Phe-Lys-NH2 - Residue count
- 5
- Molecular formula
- C38H49N9O5
- Molecular weight
- 711.9 g/mol
- CAS number
- 170851-70-4
- Chemical class
- Synthetic ghrelin-receptor agonist pentapeptide
- Classification
- Research peptide
- Alternate research names
- NNC-26-0161
- Available vial sizes
- 5 mg
Analytical verification
- Lynx report reference
- UKLY-713
- Reported purity
- 98.958%
- Analysis method
- RP-HPLC + ESI-MS
- Identity result
- Confirmed: Ipamorelin
- Analysis date
- 25 Nov 2025
- Report date
- 25 Nov 2025
Storage & Reconstitution
Store in appropriate cool, dry conditions. Refer to product-specific storage information when published.
Vials are supplied separately from bacteriostatic water and other preparation supplies.
For laboratory handling context, read Research peptide storage and stability. Product-specific information and the laboratory method take precedence.
For laboratory preparation, allow the sealed vial to reach room temperature before opening. Wipe the vial stopper and bacteriostatic-water stopper with an alcohol wipe. Add bacteriostatic water slowly down the inside wall of the vial, then swirl gently until dissolved. Do not shake.
Research literature
- Ipamorelin, the first selective growth hormone secretagogue.Raun et al. · Eur J Endocrinol · 1998PubMed
- Influence of chronic treatment with the growth hormone secretagogue Ipamorelin, in young female rats: somatotroph response in vitro.Jiménez-Reina et al. · Histol Histopathol · 2002PubMed
- The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats.Svensson et al. · J Endocrinol · 2000PubMed
Ipamorelin Price (UK)
Ipamorelin is supplied in 5 mg vials for laboratory research. The current price is £22.99.
Current availability is shown below. UK orders of £49.99 or more qualify for free standard shipping. Eligible working-day orders placed before 4 PM are dispatched the same day.
| Vial size | Current price | Price / mg | Status |
|---|---|---|---|
| 5 mg | £22.99 | £4.60/mg | Checking stock |
Common questions about Ipamorelin
What is Ipamorelin?
Ipamorelin is a synthetic five-amino-acid peptide studied as a growth-hormone secretagogue through the ghrelin-receptor pathway. Its structure includes non-standard amino acids and differs from natural ghrelin. Researchers use it to examine that receptor system and compare growth-hormone-related responses with other hormone measurements, rather than treating every secretagogue as the same molecule.
How does Ipamorelin differ from CJC-1295?
Ipamorelin acts through the ghrelin receptor, while CJC-1295 is a GHRH analogue. Both relate to growth-hormone signalling, but the signal begins at a different receptor. Comparing them helps a laboratory distinguish responses to the two pathways; a similar downstream measurement does not mean the peptides have the same structure or mechanism.
Is Ipamorelin the same as ghrelin?
No. Ghrelin is a naturally occurring peptide with a different structure; Ipamorelin is a synthetic pentapeptide, meaning it contains five amino acids. Both are associated with the ghrelin-receptor pathway, but sharing a receptor target does not make them chemically identical. Researchers distinguish the specific molecule when comparing receptor and hormone-response measurements.
How does this vial differ from CJC-1295 + Ipamorelin?
This vial contains Ipamorelin alone, allowing its ghrelin-receptor-related response to be examined separately. The blend adds CJC-1295 without DAC, bringing a GHRH-related input into the same preparation. Separate vials allow one component to be changed while the other is held constant; the supplied blend instead fixes their mass ratio.
Why is Ipamorelin described as selective?
Early animal and pituitary-cell experiments found a comparatively selective growth-hormone response when checked against other hormone measurements. 'Selective' describes that pattern of responses in those experiments, not an absence of every other effect. It helps explain why researchers compare several hormone endpoints rather than using a single growth-hormone result to describe the whole preparation.
Why are non-standard amino acids used in Ipamorelin?
Ipamorelin's sequence includes residues that differ from those usually found in natural proteins. Their shapes help define the synthetic peptide presented to the receptor, rather than making it a fragment of natural ghrelin. This is useful in molecular-design research: compounds can share a receptor target while reaching it with quite different structures.
Can I buy Ipamorelin in the UK for research?
Yes. Individual 5mg Ipamorelin vials are listed for UK laboratory research. Their stock status is separate from the CJC-1295 + Ipamorelin blend.
How is Lynx Ipamorelin batch tested?
The individual Ipamorelin report, UKLY-713, shows 98.958% purity by RP-HPLC + ESI-MS for the 5mg sample.
