Research summary
[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2008
Small comparative human study
Anxiety-score changes were reported as similar with Selank and medazepam in a comparison involving 62 patients, with additional antiasthenic observations in the Selank group. An enkephalin-related blood measurement also changed. The small clinical comparison does not provide clearly described masking or randomisation, limiting confidence in a treatment-specific interpretation.
View on PubMed: [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2014
Small comparative human study
A comparison involving 60 patients reported anxiety-scale and quality-of-life improvements with Selank, including persistence of the reported anxiety effect for a week. Limited allocation and outcome detail makes the size and reliability of the treatment-specific effect difficult to judge. The report offers early clinical context rather than a strong basis for a general claim.
View on PubMed: [A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.
Frontiers in pharmacology 2016
Cellular and animal mechanistic research
Selank changed the expression of multiple neurotransmission-related genes in rat frontal cortex. Some early changes correlated with those produced by GABA, but the pattern also involved other signalling systems. A transcriptional resemblance supports investigation of GABA-associated biology; it is not a direct demonstration of selective GABA-receptor agonism.
View on PubMed: Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.Models studied
- Psychometric research
- Behavioural models
- Neuropeptide signalling
- Neurochemical mechanisms
Key findings
Neurotransmission-related gene expression
A GABA-associated transcriptional resemblance remains different evidence from direct receptor agonism.
Early clinical comparison
The small comparative anxiety report offers human context with incompletely described allocation and masking.
A second limited clinical report
Limited clinical reporting leaves the size and reliability of the reported response uncertain.
References
[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2008
PMID 18454096
View on PubMed: [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2014
PMID 25176261
View on PubMed: [A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.
Frontiers in pharmacology 2016
PMID 26924987
View on PubMed: Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.
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