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Lynx Peptides

Human & animal studies

Semax

Regional BDNF–TrkB findings and mixed human neurological observations give Semax a more specific context than a broad cognitive claim.

Research summary

[Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 1997

Gusev EI, Skvortsova VI, Miasoedov NF, Nezavibat'ko VN, Zhuravleva EIu, Vanichkin AV

Small clinical study

Selected neurological deficits, particularly motor findings, regressed faster in a Semax group than in a conventional-treatment comparison after acute ischaemic stroke. The report compared 30 treated patients with 80 controls receiving intensive care. Without a clearly described randomised, blinded allocation, differences between the groups and their care remain plausible explanations for part of the result.

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[The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with semax].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2007

Serdiuk AV, Levitskiĭ GN, Miasoedov NF, Skvortsova VI

Small clinical study

Semax did not alter partial denervation or clinical functional estimates in an open-label series of 27 people with motor-neuron disease. Emotional and motivational quality-of-life measures improved temporarily, despite the null functional findings. Without a blinded control group, the subjective change cannot be confidently attributed to the peptide.

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Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.

Journal of neurochemistry 2006

Dolotov OV, Karpenko EA, Seredenina TS, Inozemtseva LS, Levitskaya NG, Zolotarev YA, Kamensky AA, Grivennikov IA, Engele J, Myasoedov NF

Cellular and animal mechanistic research

BDNF increased in rat basal forebrain after Semax, whereas the cerebellum did not show the same response. Specific, reversible binding was also measured in membrane preparations from the basal forebrain. The regional difference helps connect the peptide with neurotrophin biology without assuming a uniform response throughout the brain.

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Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.

Brain research 2006

Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Dubynina EV, Novosadova EV, Andreeva LA, Alfeeva LY, Kamensky AA, Grivennikov IA, Myasoedov NF, Engele J

Cellular and animal mechanistic research

Semax increased BDNF protein, BDNF and TrkB transcripts, and TrkB phosphorylation in rat hippocampus. A behavioural task also changed under the experimental conditions. These connected molecular measurements support a neurotrophin research theme, while a rodent learning task remains distinct from a human cognitive outcome.

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Models studied

  • Neurological functional measures
  • Electrophysiological observations
  • Neurotrophin-related biomarkers
  • Quality-of-life measures

Key findings

  • Regional BDNF response

    The BDNF response differed between brain regions, resisting a whole-brain interpretation.

  • Hippocampal BDNF–TrkB signalling

    Hippocampal protein, transcription and phosphorylation measurements connect Semax with BDNF–TrkB signalling in rats.

  • Human functional and subjective findings

    Subjective quality-of-life changes occurred alongside unchanged clinical function and denervation in an uncontrolled series.

  • Clinical neurological context

    Neurological differences between treated and comparison groups require caution because randomisation and masking were not clearly described.

References

  1. [Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 1997

    Gusev EI, Skvortsova VI, Miasoedov NF, Nezavibat'ko VN, Zhuravleva EIu, Vanichkin AV

    PMID 11517472

    View on PubMed

  2. [The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with semax].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2007

    Serdiuk AV, Levitskiĭ GN, Miasoedov NF, Skvortsova VI

    PMID 18379501

    View on PubMed

  3. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.

    Journal of neurochemistry 2006

    Dolotov OV, Karpenko EA, Seredenina TS, Inozemtseva LS, Levitskaya NG, Zolotarev YA, Kamensky AA, Grivennikov IA, Engele J, Myasoedov NF

    PMID 16635254

    View on PubMed

  4. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.

    Brain research 2006

    Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Dubynina EV, Novosadova EV, Andreeva LA, Alfeeva LY, Kamensky AA, Grivennikov IA, Myasoedov NF, Engele J

    PMID 16996037

    View on PubMed

For laboratory research use only. Content is provided for research reference and is not intended as medical or veterinary guidance.