Research summary
[EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].
Advances in gerontology = Uspekhi gerontologii 2015
Small uncontrolled combined human report
A small report involving Pinealon and Vesugen described changes in cellular and metabolic ageing-related measures, alongside pro-oxidant activity and lower circulating CD34-positive markers. Inconsistent participant counts and sparse methods make interpretation uncertain. Neither a favourable “biological age” conclusion nor a general antioxidant claim is justified by this report alone.
View on PubMed: [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.
International journal of molecular sciences 2024
Human induced-neuron cell model
EDR reduced oxidative DNA damage in induced neurons made from older donors’ fibroblasts. EDR and the other tested peptides also increased dendritic branching and length, while the tripeptides left mitochondrial and lysosomal activity and p16 unchanged. The mixed response is more specific than a general reversal of neuronal ageing and belongs to an in-vitro model.
View on PubMed: Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
Biochemistry. Biokhimiia 2011
Cellular and animal mechanistic research
Fluorescence-labelled Pinealon and other short peptides entered HeLa cells and produced nuclear signals. Separate fluorescence experiments suggested sequence-dependent interactions with nucleic-acid preparations. Labelling and the assay system are important context: these observations motivate mechanistic work but do not settle how unlabelled EDR regulates genes in neurons.
View on PubMed: Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.Models studied
- Small human report
- Induced-neuron cell model
- Cellular ageing markers
- EDR peptide research
Key findings
Specific neuronal changes and null endpoints
DNA-damage and dendritic findings accompanied unchanged mitochondrial, lysosomal and p16 measurements in the neuronal model.
Cell uptake and a proposed mechanism
Labelled-peptide localisation and nucleic-acid assays support further mechanistic work without establishing neuronal gene regulation.
Weak human context
Sparse reporting and inconsistent participant counts weaken a human combination report that also includes unfavourable oxidative markers.
References
[EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].
Advances in gerontology = Uspekhi gerontologii 2015
PMID 26390612
View on PubMed: [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.
International journal of molecular sciences 2024
PMID 39518916
View on PubMed: Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
Biochemistry. Biokhimiia 2011
PMID 22117547
View on PubMed: Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
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